Start your weekend with dinner and a show. Watch out-the-window projection art while you dine at Chin Chin. After-dinner, head to fortyfivedownstairs for independent theatre, or for old-school live music, prop yourself at Cherry Bar in AC/DC lane.
Fuel up at Bowery to Williamsburg and begin your art marathon in the city's key gallery precinct, in and around Flinders Lane. See contemporary Australian art at Flinders Lane Gallery and purchase locally made works from gallery and retail space, Craft.
Stroll down to Federation Square to take in the views and superb collections of Australian art at the Ian Potter Centre: NGV Australia. Don't miss the NGV Shop adjacent. Next door, if pixels are your favourite medium, immerse yourself in film, television and digital at Screen Worlds, downstairs at the Australian Centre for the Moving Image (ACMI).
See an ever-changing display of stencils, paste-ups, installations and murals on famous Hosier Lane. Admire artwork on the exterior walls of Movida Next Door, and step inside for some of Frank Comorra's legendary tapas.
After lunch, take a street art walking tour to see more of the city's urban art, or explore laneways on your own and keep an eye out for arty hidden gems.
Out of the laneway and up in an elevator, explore Swanston Street's historic Nicholas Building. It's a creative hub jam-packed with studios, galleries and curiosities. Allow time to see what's on at Blindside gallery. Below ground, enter subterranean Campbell Arcade to check out installations by the Platform Artists Group, one of Melbourne's longest-running artist run initiatives. While you're there, Sticky and Corky Saint Clair are well worth a look.
Back on street level, take the footbridge across to Southbank, with time for a drink stop at Ponyfish Island.
From here, wander up to NGV International for one of the southern hemisphere's most impressive collections of European, Asian, Oceanic and American art. Gaze through the waterwall at the front entrance and admire the world's largest, kaleidoscopic span of stained glass in the Great Hall.
Take a short stroll to the Australian Centre for Contemporary Art (ACCA) on Sturt Street to see works by leading contemporary artists.