Start your weekend watching out-the-window projection art while you dine at Chin Chin. For after-dinner performance art, head to independent theatre fortyfivedownstairs, or for old-school live music, park yourself at Cherry Bar in AC/DC lane.
Fuel up at Bowery to Williamsburg and begin your art-a-thon in the city's key gallery precinct, in and around Flinders Lane. See contemporary indigenous art at Gallery Gabrielle Pizzi and purchase locally made works from gallery and retail space, Craft.
Stroll down to Federation Square to take in the views and superb collections of Australian art at the Ian Potter Centre: NGV Australia. (Don't miss the NGV Shop adjacent.) If pixels are more your medium, immerse yourself in all things film, television and digital at Screen Worlds, downstairs at the Australian Centre for the Moving Image (ACMI).
Across the street on famous Hosier Lane, see an ever-changing display of stencils, paste-ups, installations and murals. Admire the artwork on the exterior walls of Movida Next Door, before stopping in for some of Frank Comorra's legendary tapas.
After lunch, take a street art walking tour to see more of the city's urban art, or keep exploring on your own, keeping an eye out for hidden gems in laneways.
Out of the laneways and into an elevator, explore Swanston Street's historic Nicholas Building, a creative hub jam-packed with studios, galleries and curiosities. Below the surface, enter subterranean Campbell Arcade to check out installations by the Platform Artists Group, one of Melbourne's longest-running artist run initiatives. While you're there, Sticky and Corky Saint Clair are well worth a look.
Back on street level, take the footbridge across to Southbank, allowing time for a stopover at floating bar Ponyfish Island.
From here, wander up to the NGV: International to see one of the southern hemisphere's most impressive collections of European, Asian, Oceanic and American art. Run your fingers through the irresistible waterwall at the front entrance and to admire the world's largest, kaleidoscopic stained glass ceiling in the Great Hall.
Take a short stroll to the Australian Centre for Contemporary Art (ACCA) on Sturt Street to see works by leading international and Australian contemporary artists.